B-LIF |
BLIMP1 |
IL2 enhancing factor |
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[BH3-like motif-containing cell death inducer] This is the approved gene symbol for a gene identified by Broustas et al (2004) as BRCC2 [breast cancer cell 2] in a human breast cancer cell line. BLID is a protein of 108 amino acids as deduced from its cDNA. The protein is localized predominantly in the cytosol and to a lesser extent in the mitochondria.
Exogenous expression of BLID causes cell death by apoptosis, which can be blocked by co-expression of the anti-apoptotic protein BCLxL or the broad-range inhibitor of caspases, zVAD-fmk. Expression of BLID correlates with activation of caspase-3 and
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