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Cajal-Retzius cells

[Cajal-Retzius cell, Cajal-Retzius neurons]

Called also: horizontal cells of Cajal-Retzius (Sievers and Raedler, 1981). This term pertains to a class of neurons of the embryonic marginal zone (prospective layer I) of the neocortex and hippocampus of all amniotes. These cells possess radial ascending processes that contact the pial surface, and a horizontal axon plexus located in the deep marginal zone. Cajal-Retzius cells are generated in several focal sites at the borders of the developing pallium and are redistributed by tangential migration (Bielle et al, 2005; Hevner et al, 2003). The migration process has been shown to involve the chemokine CXCL12 and its receptor CXCR4 (Paredes et al, 2006; Borrell and Marin, 2006).

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