FADD-like interleukin-1 beta-converting enzyme-2 |
FAE cells |
CXCL1-like-beta |
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[FADDosomes]
This term pertains to a protein complex consisting of FADD, RIPK1, and caspase-8. This complex promotes inflammation by initiating the expression of pro-inflammatory cytokines and chemokines (IL6, IL8, CCL2, CXCL1, and MIF [macrophage migration inhibitory factor]) following engagement of the TRAIL receptor and activation of NF-kappa-B. Inhibition of caspase-8 activity blocks apoptosis induced by TRAIL, but not cytokine production, and knock down or deletion of caspase-8
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