IRp60 |
IRQRRRR |
Kit ligand-2 |
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This peptide with the sequence IRQRRRR has been identified by Mudhakir et al (2008) through phage display library screening. The peptide acts as a cell-penetrating peptide and facilitates the uptake of peptide-modified liposomes and has been used to deliver siRNA to cells in a process involving caveolar endocytosis, a cellular uptake pathway that is involved in the blood-to-tissue uptake of macromolecules in vascular endothelial cells.
Ishitsuka et al (2011) have used IRQ peptide-modified polyethyleneglycol-coated liposomes to improve gene delivery to lung tissue and to increase transgene expression.
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