NLKAIAALAKKLL |
N-L-Methionyl-[1-165]-SCF |
IL2R-gamma |
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This peptide has been identified by Tournaire et al (2004) after phage display library screening for peptides that block the TIE-2 receptor. NLLMAAS completely abolishes the binding of the angiogenesis factors angiopoietin-1 and angiopoietin-2 to this receptor. NLLMAAS specifically suppresses both Angiopoietin-1-induced ERK activity and migration in human umbilical vein endothelial cells. In vivo, this peptide inhibits angiogenesis in the Chicken chorioallantoic membrane assay.
Wu D et al (2010) have created a fusion peptide consisting of NLLMAAS and another cell homing peptide,
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