P2 myelin |
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P2-RANTES, a variant of the chemokine CCL5, is a synthesized N-terminally modified analog of the chemokine RANTES discovered using a phage display selection against living cells expressing CCR5. In comparison with wild-type RANTES, P2-RANTES shows significantly less binding to heparin. P2-RANTES is a potent fusion inhibitor (Jin et al, 2010). P2-RANTES has been reported to inhibit cell-cell fusion mediated by the HIV1 env protein at subnanomolar levels (Hartley et al, 2003).
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