pilosulins |
PILS-AP |
HCPH |
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This putative transcription factor has been identified by Mages et al (1993). Its expression in T-cells is induced through the combined effect of phorbol 12-myristate 13-acetate and a calcium ionophore and can be suppressed fully by Cyclosporin A. In contrast to T-cells, in fibroblasts PILOT gene expression requires only one signal (phorbol 12-myristate 13-acetate) and is not affected by Cyclosporin A.
Sequence analysis shows that the protein is related to egr-1 and egr-2. The protein is identical with Egr-3.
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