Pep-1 |
PEP3 |
SH3KBP1 |
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This peptide (CGEMGWVRC) has been identified in a phage display library (Pandaya et al, 2012). It is a specific ligand of IL13RA2 [IL13R-alpha-2]
that binds the receptor with high affinity and specificity and is capable of crossing the blood-tumor-barrier and homing to glioma. Thus it has the potential to be used as a drug delivery system which confers glioma targeting property through receptor-mediated endocytosis by glioma cells. Wang et al (2014) have reported that Pep-1 functionalized to the surface of PEG-PLGA nanoparticles exhibits a significantly enhanced cellular association in rat C6 glioma cells and improved penetration in 3D avascular C6 glioma cell
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