Spi |
Spi2 |
CG8224 |
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[serine protease inhibitor-2] This serpin like protein is encoded in the genome of Ectromelia virus (Ectromelia virus serine protease inhibitor-2; Mousepox virus serine protease inhibitor-2). It inhibits caspase-1 and caspase-8 but not caspase-3, caspase-6 or granzyme B. The protein thus influences cell death by apoptosis. The protein shows a high degree of amino acid similarity with another viral protein, crmA, but is functionally different.
For other entries pertaining to cell death mechanisms see also the Apoptosis and Cell Death Dictionary section of this encyclopedia. For other relevant entries see also the
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