VYPWTQ |
VYQHQKAMKPWIQPKTKVIPYVRYL |
ICH-2 |
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This bioactive peptide has been identified by Kizawa et al (1995) in trypsin digests of casein-alpha. It corresponds to alpha-s2-casein(183-206) [casein-alpha-s2(183-206)], a fragment of alpha-s2-casein, The peptide has been shown to bind calmodulin and to inhibit calmodulin-dependent cyclic nucleotide phosphodiesterase. A peptide that is 1 amino acid longer, corresponding to corresponds to alpha-s2-casein(183-207), has the same activity.
For other proteins (or fragments thereof) with at least one additional activity that differs from the established 'classical' activity of the parent protein see also: Dual identity proteins and Cryptides MiniCOPE Dictionary.
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