peptide-morpholinos |
peptide P7 |
clonogenic assays |
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This peptide with the sequence VHWDFRQWWQPS has been identified in a phage display library as a peptide that antagonises the activity of the chemokine receptor CCR9. The peptide binds specifically to the leukemia cell line MOLT4 cells, which exhibits marked expression of CCR9. The peptide promotes cell death by apoptosis of MOLT4 cells induced by doxorubicin, and inhibits the migration of MOLT4 cells in the presence of chemokine CCL25. The authors have suggested that the peptide
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