SAF-2 |
SAG |
L-cell colony stimulating factor |
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[sensitive to apoptosis gene] This gene is known also as ROC-2, Rbx-2, Hrt-2, and CKBBP1 [CKII beta-binding protein 1; casein kinase 2-beta binding protein 1]. It has been identified as a component of SCF-E3 ubiquitin ligase, which controls cell cycle progression by promoting ubiquitination and degradation of cell cycle inhibitors (Swaroop et al, 2001). The human gene has been mapped to chromosome 3q22-24.
The gene encodes a zinc RING finger protein (113 amino acids; 12.6 kDa). The approved gene symbol is RNF7 [RING finger protein 7]. sag is highly conserved during evolution (70 % identity between
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