A39R |
A46 protein |
G-protein-coupled receptor-73 |
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This vaccinia virus gene (Vaccinia virus A41L protein) encodes a soluble 30 kDa glycoprotein that affects virus virulence but is not essential for virus replication. The protein is secreted from virus-infected cells.
A41L has immunomodulatory activities and is similar to vCKBP and GIF, which have been identified as proteins bindig chemokines and GM-CSF or IL2, respectively. The protein is considered a homolog of vCKBP-2. An ortholog from ectromelia virus has been identified as E163.
Bahar et al (2008) have reported that the protein binds CCL21, CCL25, CCL26, and
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