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A41L

This vaccinia virus gene (Vaccinia virus A41L protein) encodes a soluble 30 kDa glycoprotein that affects virus virulence but is not essential for virus replication. The protein is secreted from virus-infected cells.

A41L has immunomodulatory activities and is similar to vCKBP and GIF, which have been identified as proteins bindig chemokines and GM-CSF or IL2, respectively. The protein is considered a homolog of vCKBP-2. An ortholog from ectromelia virus has been identified as E163.

Bahar et al (2008) have reported that the protein binds CCL21, CCL25, CCL26, and ... ... ... ... ... Subscribe to continue reading! ... ...

 

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