Abhisin |
ABIN-2 |
Cytomegalovirus immediate early 72 protein |
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[A20-binding inhibitor of NF-kappa-B activation-1] The approved gene symbol for this factor is TNIP1 [TNFAIP3 interacting protein 1].
This protein binds to the TNF inducible protein A20, which is a potent inhibitor of gene expression mediated by NF-kappa-B in response to TNF and several other stimuli. ABIN-1 inhibits TNF induced activation of NF-kappa-B upon overexpression (Heyninck et al, 2003; Klinkenberg et al, 2001). El Bakkouri et al (2005) have reported that adenoviral transfrer of ABIN-1 to lung epithelial cells decreases allergic airway infllamation in a murine asthma model.
ABIN-1 is identical with
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