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ABIN-2

[A20-binding inhibitor of NF-kappa-B activation-2] The approved gene symbol for this factor is TNIP2 [TNFAIP3 interacting protein 2]. The protein has been identified independently as FLIP1.

ABIN-2 binds to the C-terminal zinc finger domain of A20, which is a potent inhibitor of gene expression mediated by NF-kappa-B in response to TNF and several other stimuli (Van Huffel et al, 2001). Overexpression of ABIN-2 inhibits activation of transcription factor NF-kappa-B induced by TNF-alpha and IL1 or overepression of TRAF2. NF-kappa-B ... ... ... ... ... Subscribe to continue reading! ... ...

 

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