ABIN-1 |
ABIN-3 |
tripartite motif-containing protein 5 |
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[A20-binding inhibitor of NF-kappa-B activation-2] The approved gene symbol for this factor is TNIP2 [TNFAIP3 interacting protein 2]. The protein has been identified independently as FLIP1.
ABIN-2 binds to the C-terminal zinc finger domain of A20, which is a potent inhibitor of gene expression mediated by NF-kappa-B in response to TNF and several other stimuli (Van Huffel et al, 2001). Overexpression of ABIN-2 inhibits activation of transcription factor NF-kappa-B induced by TNF-alpha and IL1 or overepression of TRAF2. NF-kappa-B
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