ACDCR2 |
ACDCRGDCFCG |
Ly24 |
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This targeting peptide has been isolated by phage display library screening. It contains an RGD sequence motif and has been shown to act as a cell-targeting peptide that binds to human integrins integrin-alpha-V / integrin-beta-3 and integrin-alpha-V / integrin-beta-5 (Pasqualini et al, 1997; Koivunen et al, 1995).
Kim et al (2005) have incorporated the ACDCRGDCFC peptide into the cationic polymer polyethylenimine via a hydrophilic polyethylene glycol spacer and used this for gene delivery of a gene encoding a soluble fragment of the VEGF receptor flt-1 (VEGFR1), which antagonizes angiogenesis mediated by
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