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ADAM18

[a disintegrin and metalloprotease domain 18; ADAM metallopeptidase domain 18] This designation has been given to a member of the ADAM protein family, tMDC-3 [transmembrane metalloproteinase-like, disintegrin-like, cysteine-rich 3]. A databank synonym, according to HGNC, is ADAM27 [a disintegrin and metalloprotease domain 27].

Zou et al (2018) have identified ADAM18 as one of 12 markers of cancer-associated fibroblasts that are upregulated in these fibroblasts in hepatocellular carcinoma and are associated with the pathological and clinical progressions of these tumors.

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