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ADAMTS14

[a disintegrin and metalloproteinase with thrombospondin motif-14; ADAM metallopeptidase with thrombospondin type 1 motif 14] This enzyme acts as a physiological aminoprocollagen peptidase. It displays striking homologies with ADAMTS2 and ADAMTS3. The human gene maps to chromosome 10q21.3.

ADAMTS14 together with some other membersx of the ADAM protein family has been found to be upregulated consistently in breast carcinomas (Porter et al, 2004).

See also: ADAM protein family. For other entries pertaining to metalloproteinases see also the Metalloproteinase Dictionary section of this encyclopedia.

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