AHV-1 semaphorin |
AHWSGHCCL |
LSFMAIPPK |
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This protein is encoded by an open reading frame of AHV-1, a rhadinovirus (gamma2-herpesvirus) that causes malignant catarrhal fever of ruminants (Ensser and Fleckenstein, 1995; Ensser et al, 1997). The mouse and human homologous proteins are known as SEMA7A (see: semaphorins). It has been suggested that the viral protein may interfere with cellular apoptosis or immune functions. AHV-Sema binds to the VESPR receptor.
For other relevant entries see also the Pathogenicity/Virulence Factors Dictionary section of this encyclopedia.
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