ALG2 interacting protein X |
ALG4 |
CD239 |
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[Apoptosis-linked gene-3] The gene encodes a truncated form of presenilin-2 encoded by the familial Alzheimer's disease gene, STM2. Reduction of presenilin-2 protein levels by antisense RNA protects from apoptosis, whereas overexpression of a mutant protein increases cell death induced by several stimuli.
ALG3 is a potent inhibitor of apoptosis. Expression of ALG3 rescues a T-cell hybridoma from apoptosis induced by T-cell receptor and APO-1. Expression of the gene protects rat pheochromocytoma PC12 cells from apoptosis induced by glutamate and
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