ALKAL1 |
ALK and LTK ligand 1 |
GACRRETAWACGA |
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(approved gene symbol) [ALK and LTK ligand 2] An alternative designation for this protein is FAM150B [family with sequence similarity 150 member B]. The protein has been named AUGA or AUG-alpha [augmentor-alpha] and is related to ALKAL1 (Reshetnyak et al, 2015). ALKAL2 is a secreted protein that binds anaplastic lymphoma kinase ALK as a ligand with high affinity and causes cell activation. The protein is also a ligand for LTK [leukocyte tyrosine kinase]. Expression of ALKAL2 stimulates transformation of NIH 3T3 cells expressing ALK, induces
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