AMFR |
AMGAP |
DGGEEQTLSTEAETWEGAGPSIQLQLQEVKGKASQFFGLM |
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This compound is a hyperglycosylated analog of recombinant human erythropoietin. In preclinical studies, AMG 114 demonstrates increased potency and longer half-life than darbepoetin alfa and epoetin-alfa. Although AMG 114 appears to be well tolerated, a Phase I/II randomised study for the treatment of anaemia with concomitant chemotherapy in patients with non-myeloid malignancies was halted, in part because of modest efficacy (De Boer et al, 2011).
An increased incidence of thrombotic toxicities in Sprague-Dawley rats administered the highest dose level of AMG 114 has been shown to be due to the expression of pleiotropic cytokines as prothrombotic factors associated with AMG 114 dose level (CCL2 (MCP-1), CCL7 (MCP-3),
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