AMP-18
[Antrum mucosal protein 18 kDa] This murine protein of 18 kDa is synthesized and secreted by epithelial cells of the gastric antrum mucosa. The sequences of the human and pig proteins (185 and 184 amino acids, respectively) are highly conserved (Martin et al, 2003).
AMP-18 and a functional 21-mer peptide derived from AMP-18 (AMP-18(77-97), have been shown to stimulate growth of gastric and intestinal epithelial cells, but not fibroblasts, and to increase wound healing in scrape-wounded gastric epithelial monolayers. Growth is stimulated also by peptide AMP-18(84-97) (KKLQGKGPGGPPPK) and
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