AREG |
Arenavirus Z-proteins |
monocytic leukemia-associated antigen |
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[apoptosis resistant E3 ubiquitin protein ligase 1] This gene has been identified independently as KIAA0317.
AREL1 is a cytosolic E3 ubiquitin ligase identified by Kim et al (2013). Ubiquitination and degradation of cytosolic forms of three IAP antagonists plays an important role in the regulation of apoptosis. AREL1 interacts with and ubiquitinated IAP antagonists such as SMAC [second mitochondria-derived activator of caspase], HtrA2 [HTRA serine peptidase 2], and ARTS [apoptosis-related protein in the TGF-beta signaling pathway]. The interactions between AREL1 and the IAP antagonists is specific for apoptosis-stimulated
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