ARTS |
ARVC10 |
glycoprotein 3b |
||
[aminopeptidase regulator of TNFR1 shedding 1] The protein is identical with A-LAP [adipocyte-derived leucine aminopeptidase].
ARTS-1 is a type 2 integral membrane protein. It binds to the extracellular domain of the TNF receptor 1. Cells overexpressing ARTS-1 demonstrate increased TNFR1 receptor shedding and decreased membrane-associated TNF receptor.
ARTS-1 appears to be specific for the TNF receptor type 1 and does not interfere with TNF receptor type 2. ARTS-1 itself does not seem to possess TNF R1 sheddase activity and may be part of a complex promoting TNF
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