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ASFV I329L

[African swine fever virus ORF I329L] ASFV I329L of African swine fever virus encodes a host evasion protein that acts as an inhibitor of Toll-like receptor signaling (de Oliveira et al, 2011). ORF I329L encodes a highly glycosylated protein expressed in the cell membrane and on its surface. I329L inhibits dsRNA-stimulated activation of NF-kappa-B and IRF3, two key players in innate immunity. Expression of I329L protein also inhibits the activation of IFN-beta and chemokine CCL5. Overexpression of TRIF, a signaling adaptor critically involved in the TLR3 and TLR4 signaling pathways for type 1 interferon ... ... ... ... ... Subscribe to continue reading! ... ...

 

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