Ac-VAD-CMK |
ACVR1 |
src homology domain-3 |
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This peptide, (N-Acetyl-derivative of VDTTD conjugated to 7-amino-4-trifluoromethyl coumarin) has been described by Kitevska et al (2014) to be a peptide substrate selective for caspase-2 in mammalian cells (see also: VDVAD).
General note on chemical modifications: Practically all of the available caspase inhibitors, be they specific or pan-caspase inhibitors, come in chemically modified form. The introduction of an aldehyde group at the C-terminus of the short peptide sequences recognized by caspases
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