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Angiomodulin

abbr. AGM. This factor is secreted by tumor blood vessels (see also: angiogenesis) and is present on the surface of endothelial cells (Akaogi et al, 1996). In cell culture, it promotes cell adhesion and morphological changes to form cord-like structures of the human bladder carcinoma cell line ECV-304. Cord formation is prevented by heparin, which inhibits the binding of Angiomodulin to ECV-304 cells.

Angiomodulin may be involved in angiogenesis and modulation of the vascular functions necessary for tumor development. Expression of angiomodulin in invading tumor cells correlates with poor prognosis in human colorectal cancer (Adachi et al, 2000).

Angiomodulin has been shown to be identical with TAF (tumor-derived adhesion factor), IGFBPrP1, mac25, PSF (Prostacyclin stimulating factor).

The protein is cleaved at the cell surface to a tw0-chain form, which abolishes its ability to bind IGF-1 and associated growth-stimulatory activities. The processing enzyme has been identified as Matriptase (Ahmed et al, 2006).

See also: Angiogenesis Dictionary section of this encyclopedia for other entries directly bearing on factors and processes involved in the generation of new blood vessels.

LAST MODIFIED: March 2002

See REFERENCES for entry Angiomodulin

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