ANLERTFIAIKPDGV |
Annetocin |
GPRA-A |
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This protein, termed also anthralysin O, is one of the hemolytic proteins of Bacillus anthracis produced under strict anaerobic growth conditions (Klichko et al, 2003; Read et al, 2003). It encodes a protein with sphingomyelinase activity, as inferred from a homologous gene in Bacillus cereus.
Popova et al (2006) have reported that the isolated Bacillus anthracis hemolytic protein causes the accelerated shedding of Syndecan-1 (CD138) and E-cadherin (CD324) from epithelial cells and compromises epithelial barrier integrity within a few hours.
AnlO does not act directly but is a shedding inducer. Its action involves the stimulation of cytoplasmic tyrosine kinases
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