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Annetocin

Annetocin (CFVRNCPTGamide) is a neuropeptide related to oxytocin isolated from the whole body of a lumbricid earthworm Eisenia foetida (Oumi et al, 1994). The peptide is a member of the vasopressin / oxytocin superfamily (Satake et al, 1999).

Takahama et al (1998) have shown that the neuropeptide is produced and secreted by the neuron in the cerebral and subesophageal ganglia of the earthworm. Annetocin potentiates not only spontaneous contractions of the gut but also pulsatory contractions and bladder-shaking movement of the nephridia and may be involved in osmoregulation.

Annetocin also induces egg-laying-like behaviors in E. foetida and a gnathobdellid leech, Whitmania pigra (Oumi T et al, 1996).

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