Anti-Jo-1 syndrome |
Antileukoproteinase |
Type 2 hematopoietins |
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This synthetic hexapeptide with an acetylated amino terminus and an amidated carboxyl terminus (Ac-RRWWCRamide) has been shown to inhibit the specific binding of IL8 to neutrophils. The peptide inhibits chemotaxis in neutrophils, release of beta-glucuronidase from neutrophils, and rabbit skin edema induced by IL8.
The peptide also suppresses the binding of MIP-2-beta to neutrophils. It does not inhibit the binding of MIP-1-alpha, C5a, or leukotriene B4 to neutrophils, chemotaxis induced by fMLP, or beta-glucuronidase release induced by fMLP
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