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Arenavirus Z-proteins

[Arenavirus Z-protein]

This protein is encoded by a number of enveloped single-stranded RNA viruses with bisegmented genomes known as Arenaviruses. Some of these viruses can cause hemorrhagic fevers in humans.

Z-protein is a small zinc-binding RING finger protein that interacts with a variety of cellular proteins (Borden et al, 1998; Campbell Dwyer et al, 2000; Djavani et al, 2005) and is important for virus budding (Strecker et al, 2003; Perez et al, 2003)..

Z-protein also plays a role in immune evasion. Fan et al (2010) have shown that Z-proteins of GTOV (Guanarito virus), JUNV (Junin virus), MACV (Machupo virus), and SABV (Sabia virus), but not that of LCMV (lymphocytic choriomeningitis virus) or LASV (Lassa virus), bind to RIG-I, interfere with the interaction between ... ... ... ... ... Subscribe to continue reading! ... ...


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