Asp-Pro-Ser-Phe-Asn-Ser-Trp-Glyamide |
Asp-Tyr-Met-Gly-Trp-Met-Asp-Phe |
Beta-Defensin-12 |
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Asprosin is a cleavage product derived from the C-terminal end of profibrillin (see below). Asprosin is fasting-induced protein adipokine secreted by white adipose tissue adipocytes in response to fasting (Romere et al, 2016). It is a counter-regulatory hormone to insulin, is found in the circulation at nanomolar levels, and is recruited to the liver, where it causes the rapid release of glucose into the circulation. Circulating asprosin also results in metabolic syndrome, while a reduction in asprosin levels protects against hyperinsulinemia related to metabolic syndrome (Romere et al, 2016). Humans and mice with insulin resistance show pathologically elevated levels of plasma asprosin, and its loss of function has a profound glucose- and insulin-lowering effect secondary to reduced hepatic glucose release.
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