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(approved gene symbol) [B-cell lymphoma/leukemia-9-like] This gene is known also as BCL9-2 [B-cell lymphoma/leukemia-9-2] (Brembeck et al, 2004). The human and mouse genes, which show 94 % identity, have been identified by Katoh and Katoh (2003). The encoded protein has a nuclear localization signal but no signal peptide or transmembrane domain. BCL9L is considered to be one of two vertebrate homologs of Drosophila melanogaster gene legless, which is required for Armadillo / beta-catenin signaling in the fly.
Brembeck et al (2004) have reported that BCL9L induces epithelial-to-mesenchymal transition
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