BCM-11 |
Bcmd |
CCX-CKR |
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[B-cell maturation protein] Also abbr. BCM (Laabi et al, 1992). This protein is related to the TNF receptor and belongs to the TNF receptor superfamily and has been given the designation TNFRSF17 [TNF receptor superfamily member 17]. The BCM gene has been cloned by Laabi et al (1992) who identified it through a gene affected by a translocation in a malignant T-cell lymphoma.
The protein has been shown to bind to BLyS [B-lymphocyte stimulator] (Gross et al, 2000) and also to APRIL (Marsters et al, 2000). APRIL binds BCMA with higher affinity than TACI. Both proteins activate
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