Beta-1,6-N-acetylglucosaminyltransferase-5 |
beta-actin |
TIS11b |
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This factor of 35 kDa has been identified and purified from the conditioned medium of mouse tumor cells derived from pancreatic Beta-cells tumor cells (Liang et al, 2011). Beta-35 inhibits DNA synthesis of bovine capillary endothelial cells and blocks angiogenesis in the chicken chorioallantoic membrane assay. Recombinant Beta-35 shows significant anti-tumor activity at a dose of 5mg/kg/day against human pancreatic cancer or melanoma implanted subcutaneously in SCID mice.
See also: Angiogenesis Dictionary
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