C12 Peptide |
C13orf15 |
Fasciclin, EGF-like, laminin-type EGF-like and link domain-containing scavenger receptor 2 |
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This peptide with antibacterial activities corresponds to the last 13 amino acids of the carboxyl terminus of human platelet factor-4 (PLYKKIIKKLLES; corresponding to PF4(58-70) [platelet factor-4(58-70)]). C18G is a peptide analogue with 80-fold higher antibacterial activity than C13. C18G or an analogue with all D-amino acids (C18X) significantly increases the survival of neutropenic mice when coadministered with a low level of cefepime (Darveau et al, 1992).
C18G exhibits potent anticancer peptide activity against a variety of tumor cell lines. The lytic activity of
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