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CAS

[cellular apoptosis susceptibility gene] The cDNA for this gene was identified by virtue of its ability to render MCF-7 breast cancer cells resistant to cell death by apoptosis caused by the ADP-ribosylating toxins Pseudomonas exotoxin, Pseudomonas exotoxin-derived immunotoxins, diphtheria toxin, and TNF-alpha and TNF-beta (Brinkmann et al, 1995, 1996).

Human CAS (971 amino acids) and yeast CSE1, a gene essential for chromosome segregation and necessary for B-type cyclin degradation in mitosis, are considered to be homologous (Brinkmann et al, 1995). Thus, the protein has been termed ... ... ... ... ... Subscribe to continue reading! ... ...

 

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