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CATF

[Cartilage-derived anti-tumor factor] This biochemically uncharacterized factor has been extracted from bovine cartilage (Takigawa et al, 1985). CATF inhibits the growth of solid murine sarcoma 180, but not the growth of ascites tumors of sarcoma 180. CATF also inhibits the proliferation and DNA synthesis of endothelial cells isolated from bovine pulmonary artery, but not the proliferations of sarcoma 180, L1210 and L cells, suggesting that the factor interferes with tumor angiogenesis in solid tumors.

An identical or similar factor has been found in the serum-free conditioned medium of rabbit costal chondrocytes ... ... ... ... ... Subscribe to continue reading! ... ...

 

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