CCHamide-1 receptor |
CCHamide-2 receptor |
Aschoff cells |
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This Drosophila melanogaster peptide (GCQAYGHVCYGGHamide) is encoded by gene CG14375. The peptide is found also in other arthropods. The CCHamide-2 preproprotein is 136 amino acid residues long and contains three forms of CCHamide-2 (Ida et al, 2012). CCHamide-2 is considered a brain-gut peptide and has been shown to be expressed predominantly in the brain and midgut (Reiher et al, 2011).
The peptide utilizes two G-protein-coupled receptors encoded by genes CG14593, termed CCHa2-R [CCHamide-2 receptor], and CG30106, termed CCHa1-R
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