CD11b(+)Gr-1(dim) tolerogenic dendritic cell-like cells |
CD11b(+) Gr-1(+) myeloid cells |
Interleukin-14-alpha |
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This biochemically uncharacterized factor(s) of 9-12 and 27-32 kDa is found in the conditioned medium of hepatocytes derived from rats after short term endotoxin infusion (Zhang et al, 1994).
The factor upregulates expression of CD11b CD11c in polymorphonuclear leukocytes and is chemotactic for these cells obtained from naive rats. The factor is produced also by Kupffer cells and liver macrophages. The activity of this factor is not neutralized by antibodies directed against rat IL8.
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