CHAK
[CC-Chemokine-activated killer] A name given to cytolytic cells similar to cells activated by IL2 (see: LAK cells).
CD4(+) or CD8(+) cells do not generate CHAK activity. CHAK activity is obtained by incubating CD56(+) cells with certain members of the CC-Chemokines (MIP-1-alpha, MIP-1-beta, MCP-1, and RANTES). IL8 does not induce CHAK activity. The presence of other cell types, such as cells expressing CD4 or CD8, is necessary to induce the proliferation of
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