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Cytokines & Cells Online Pathfinder Encyclopaedia

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CLE

[Conserved lymphokine element] This sequence element is known also as the CSF box due to its presence in the promoters of colony stimulating factors (see: CSF).

CLE consists of a highly conserved decanucleotide (5'-GGAGATTCCA-3') found at positions -99 to -108 in the promoter regions of many lymphokine genes, including, for example, the genes encoding IL2, IL3, IL4 IL5, IFN-gamma, G-CSF and GM-CSF.

CLE serves as a binding site for specific DNA binding proteins that function as transcription factors and influence the expression of those genes containing a CLE (see also: gene expression). Optimum binding is stimulated by phorbol 12-myristate 13-acetate (see also: Phorbol esters) and Calcium ionophores (A23187).

For a related conserved element see also: Cytokine 1.

See also: Response elements.

See REFERENCES for entry CLE

CLE

The following COPE entries contain this entry term or one of its hypertext synonyms:

Colony stimulating factor box, conserved lymphokine element, CSF box, Cytokine 1, Early response gene, G-CSF, GM-CSF, IL4, IL5, Phorbol esters, Response elements.

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