CLE

[Conserved lymphokine element] This sequence element is known also as the CSF box due to its presence in the promoters of colony stimulating factors (see: CSF).

CLE consists of a highly conserved decanucleotide (5'-GGAGATTCCA-3') found at positions -99 to -108 in the promoter regions of many lymphokine genes, including, for example, the genes encoding IL2, IL3, IL4 IL5, IFN-gamma, G-CSF and GM-CSF.

CLE serves as a binding site for specific DNA binding proteins that function as transcription factors and influence the expression of those genes containing a CLE (see also: ... ... ... ...
 
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