CPNGRC |
CPP32 |
contraction-band necrosis |
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[Collagen potentiated neurite promoting factor] This biochemically uncharacterized factor is produced by C6 glial cells grown in a defined medium on a collagen substratum.
CPNPF promotes the outgrowth of neurites in PC12 cells but not in mouse neuroblastoma cells (Neuro-2a). CPNPF activity is not blocked by neutralizing antibodies against NGF, bFGF, IL1-beta, IL6, TGF-beta-2, TGF-beta-1.2, TGF-beta-3, TGF-beta-5, or EGF. CPNPF also does not appear to be identical with glial derived protease Nexin-1.
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