CRF2-4
[cytokine receptor family 2 member 4] CRF2-4 is a member of the type 2 cytokine receptor family (Gibbs and Pennica, 1997). The gene, CRFB4 (Lutfalla et al, 1993), maps to human chromosome 21 in the vicinity of genes encoding IFN receptor subunits. The approved gene symbol is IL10RB [IL10 receptor-beta; IL10R-beta; interleukin-10 receptor-beta].
CRF2-4 has been identified as a membrane-spanning receptor chain of the IL10 receptor (IL10R2) (Kotenko et al, 1997). The ligand has been identified as IL22 (see: IL-TIF).
Knock-out experiments in transgenic
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