CSPGAK |
Cs-pgrn-1 |
CD83b |
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[CSPGAKVRC]
This peptide with the sequence Cys-Ser-Pro-Gly-Ala-Lys-Val-Arg-Cys, termed UNO peptide by the authors, has been identified in a phage display screen on peritoneal macrophages in mice with breast cancer. The peptide is a tumor homing peptide. Intravenously injected UNO peptide homes to tumor and sentinel lymph node macrophages that express CD206 in different cancer models: 4T1 and MCF-7 breast carcinoma, B16F10 melanoma, WT-GBM glioma and MKN45-P gastric carcinoma. UNO peptide is specific for these tumor-infiltrating macrophages, is internalised by these
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