Caspase-8 interacting protein 1 |
caspase-8 p41 |
PLLQATAGGGS |
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This isoform of caspase-8 is generated by alternative splicing of human caspase-8 gene.
Caspase-8L does not possess the catalytic site of caspase-8 but retains 2 N-terminal repeats of the death effector domain. Caspase-8L protein is expressed in human peripheral blood lymphocytes. In MCF-7 cells, caspase-8L transfection itself does not affect cell viability but instead inhibits cell death by apoptosis induced by the cotransfection of caspase-8 in a dominant negative manner. Expression of Caspase-8L in Jurkat cells inhibits cell death by apoptosis induced by
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