Chaperokine |
Chaperone-mediated autophagy |
BOK-L |
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abbr. casa. Chaperone-assisted selective autophagy is a degradative process involving autophagy that utilizes BAG3 [BCL2-associated athanogene-3], the mammalian functional homolog of the Drosophila melanogaster co-chaperone Starvin. Chaperone-assisted selective autophagy differs from Chaperone-mediated autophagy, which also uses chaperones for lysosome-dependent degradation, in its requirement for ubiquitination of the substrates and the involvement of autophagy proteins.
A target of Chaperone-assisted selective autophagy at the Z-disk, a protein assembly essential for actin anchoring in striated muscles, is the actin-crosslinking protein FLNC [filamin-C-gamma] recognised by the
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