charybdis
also: charybde. This Drosophila protein, encoded by CG7533, has been identified as a growth suppressor in an enhancer/promoter overexpression screen and acts as negative regulator of growth. Expression is induced under hypoxic conditions (Reiling and Hafen, 2004). Scuderi et al (2006) have shown that charybdis is required for embryonic head involution. Gene disruption studies reveal the functional redundancy of charybdis and another gene, scylla
Charybdis is the paralog of the human apoptotic gene REDD2 [regulated in development and DNA damage response 2], which thus links patterning and cell death.
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